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AnnoDUF
AnnoDUF is a comprehensive database for DUFs that also offers algorithms to provide
putative annotations for newly identified protein sequences. This can enhance understanding of biological processes and aid in
drug discovery. The homepage features a brief overview of the database content and its algorithms.
The figure above shows that users can select a DUF ID by clicking on the "Select" option and choosing the DUF ID with their research interest.
For example, a DUF ID "DUF123" is been selected for the analysis
The figure above shows that users can upload a FASTA file by clicking on the "Choose File" option, or
they can directly submit the FASTA sequence in the text area provided. For example, a FASTA sequence of
a PD-(D/E)XK motif protein has been submitted in the text area.
The figure above shows that users can run an example by clicking on the "Example" button. After selecting
the DUF ID, uploading a FASTA file, or submitting the FASTA sequence of the protein of interest
in the text area, users should click on the "Analyze" button to identify the putative annotation of the
protein. Additionally, users can reset all fields by clicking on the "Reset" button.
The figure above shows the summary table that users will receive after submitting their query and
completing the analysis. This interactive table allows users to search for keywords using the search box
located at the top right corner of the table. Users can also download the table by clicking the
"Download" button at the top left corner. Additionally, pagination options are available at the bottom
right corner, enabling easier navigation throughout the table.
The figure above shows an interactive graphical summary that visually represents the distribution of
domains within the DUFs using a pie chart. Each segment of the pie chart indicates the percentage of
distinct domains found in the DUF sequence collection. The images are available for download in .png,
.jpeg, .pdf, and .svg formats, and the data used to create the pie chart is also downloadable.
Additionally, clicking on "Reset to Home" will redirect users to the AnnoDUF homepage.
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