X-Pro is a computational tool designed to unravel the potential rotameric configurations that result from a point mutation within a protein structure. This tool harnesses the powerful functionalities of two readily accessible software programs: PyMOL and Modeller. It further employs LigPlot to explore changes in interactions between the mutated amino acid and its neighbouring residues. To understand the potential pathogenicity of the mutation, FoldX, DynaMut2, DUET, mCSM, SDM, and HOPE are used to assess mutation-induced changes in protein stability and structural properties, providing insights into the possible pathogenic effects of the mutation.

If you find this tool to be useful and if the result lead to publication, please cite the following: Aman Vishwakarma, Anurag N, Nadimpally Sai Tharun Goud, Chandreyee Nandi, Sudha Srinivasan, S. Thiyagarajan.

This work is funded by Indian Council of Medical Research (ICMR).